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About us

3Dnamics is a leading commercial-stage biotech company focusing on pluripotent stem cell-derived products, assays, and research contract services. We strive to innovate new technologies and are committed to scientific excellence.



Ha Nam Nguyen, PhD
Co-founder & CEO


Hongjun Song, PhD


Guo-li Ming, MD/PhD




Scientific Puplications*
(*Representative publications from 3Dnamics' founders)
  • Nguyen, H.N. (2022). Generation of iPSC-derived Brain Organoids for Drug Testing and Toxicological Evaluation. Methods in Molecular Biology 2474, 93-105. Read article
  • Qian, X., Jacob, F., Song, M.M., Nguyen, H.N., Song, H., Ming, G.L. (2018). Generation of human brain region-specific organoids using a miniaturized spinning bioreactor. Nature Protocols 13, 565-580. Read article
  • Nguyen, H.N., Song, H., Ming, G.L., (2016). Engineering human pluripotent stem cell-derived 3D brain tissues for drug discovery. Journal of Translational Neuroscience 1(2), 38-48. Read article
  • Xu M., Lee E.M, Wen, Z., Cheng, Y., Huang, W.K., Qian, X., TWC, J., Kouznetsova, J., Ogden, S.C., Hammack, C., Jacob, F., Nguyen, H.N., Itkin, M., Hanna, C., Shinn, P., Allen, C., Michael, S.G., Simeonov, A., Huang, W., Christian, K.M., Goate, A., Brennand, K., Huang, R., Xia, M., Ming, G.L., Zheng, W., Song, H. and Tang H. (2016). Identification of small molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nature Medicine 22, 1101-1107. Read article
  • Qian, X., Nguyen, H.N., Song, M.M., Hadiono, C., Ogden, S. C., Hammack, C., Yao, B., Hamersky, G., Jacob, F., Zhong, C., Yoon, K.J., Jeang, W., Lin, L., Li, Y., Thakor, T., Berg, D.A., Zhang, C., Kang, E., Chickering, M., Nauen, D., Ho, C.Y., Wen, Z., Christian, K.M., Shi, P.Y., Maher, B.J., Wu, H. Jin, P., Tang, H., Song, H., Ming, G.L. (2016). Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure. Cell 165, 1238-1254. Read article
  • Wen, Z., Nguyen, H.N., Guo, Z., Lalli, M.A., Wang, X., Su, Y., Kim, N.S., Yoon, K.J., Shin, J., Zhang, C., Markri, G., Nauen, D., Yu, H., Guzman, E., Chiang, C.H., Yoritomo, N., Kaibuchi, K., Zou, J., Christian, K.M., Cheng, L., Ross, C.A., Margolis, R., Chen, G., Kosik, K.S., Song, H, Ming, G.L. (2014). Synaptic dysregulation in a human iPSC model of mental disorders. Nature 515, 414-418. Read article
  • Yoon, K.J., Nguyen, H.N., Ursini, G., Zhang, F., Kim, N.S., Wen, Z., Makri, G., Shin, J.H., Park, Y., Chung, R. Pekle, E., Zhang, C., Towe, M., Hussani, Q., Lee, Y., Rujescu, D., St Clair, D., Kleinman, J.E., Hyde, T.M., Krauss, G., Christian, K.M., Rapoport, J.L, Weinberger, D.R., Song, H., and Ming, G.L. (2014). Mental disorder risk gene CYFIP1 maintains adherens junctions and polarity of human and mouse cortical neural stem cells. Cell Stem Cell 15, 79-91. Read article
  • Juopperi, T.A., Kim, W.R., Chiang, C.H., Yu, H., Margolis, R.L., Ross, C.A., Ming, G.L., Song, H. (2012). Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells. Molecular Brain 5: 17. Read article
  • Nguyen, H.N., Byers, B., Cord, B., Shcheglovitov, A., Byrne, J., Gujar, P., Kee, K., Schüle, B., Dolmetsch, R.E., Langston, W., Palmer, T.D., and Reijo Pera, R (2011). Lrrk2 mutant ipsc-derived DA neurons demonstrate increased susceptibility to oxidative stress. Cell Stem Cell 8, 267-280. Read article
  • Batista, L. F., Pech, M. F., Zhong, F. L., Nguyen, H. N., Xie, K. T., Zaug, A. J., Crary, S. M., Choi, J., Sebastiano, V., Cherry, A., Giri, N., Wernig, M., Alter, B. P., Cech, T. R., Savage, S. A., Reijo Pera, R. A., and Artandi, S. E. (2011). Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature 474, 399-402. Read article
  • Byers, B., Cord, B., Nguyen, H.N., Schüle, B., Fenno, L., Lee, P.C., Deisseroth, K., Langston, J.W., Reijo Pera, R., and Palmer, T.D. (2011). SNCA Triplication Parkinson’s Patient’s iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress. PLoS One 6, e26159. Read article
  • Rufaihah A.J., Huang N.F., Jame S., Lee J., Nguyen H.N., Byers B., De A., Okogbaa J., Rollins M., Reijo-Pera R., Gambhir S.S., and Cooke J.P. (2011). Endothelial cells derived from human iPSCs increase capillary density and improve perfusion in a mouse model of peripheral arterial disease. Arterioscler Thromb Vasc Biol. 31, e72-e79. Read article
  • Panula, S., Medrano, J.V., Kee, K., Bergstrom, R., Nguyen, H.N., Byers, B., Wilson, K.D., Wu, J.C., Simon, C., Hovatta, O., and Reijo Pera, R.A. (2011). Human germ cell differentiation from fetal- and adult-derived induced pluripotent stem cells. Hum Mol Genet. 20, 752-762. Read article
  • Byrne, J.A., Nguyen, H.N., and Reijo Pera, R.A. (2009). Enhanced generation of induced pluripotent stem cells from a subpopulation of human fibroblasts. PLoS One 4, e7118. Read article
  • Kossack, N., Meneses, J., Shefi, S., Nguyen, H.N., Chavez, S., Nicholas, C., Gromoll, J., Turek, P.J., and Reijo-Pera, R.A. (2009). Isolation and characterization of pluripotent human spermatogonial stem cell-derived cells. Stem Cells 27, 138-149. Read article
  • Chavez, S.L., Meneses, J.J., Nguyen, H.N., Kim, S.K., and Pera, R.A. (2008). Characterization of Six New Human Embryonic Stem Cell Lines (HSF7, -8, -9, -10, -12, and -13) Derived Under Minimal-Animal Component Conditions. Stem Cells and Dev. 17, 535-546. Read article

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